Endocrine Abstracts

Background: Maturity-onset diabetes of the young (MODY) is a group of 13 monogenic forms of diabetes transmitted in an autosomal dominant pattern and is characterized by a primary defect in pancreatic β-cell function. This disease has an early onset, usually before 25 years of age. It may present with mild asymptomatic hyperglycemia with progressive development to clinical diabetes mellitus. First-line treatment relies on sulphonylureas or insulin according to MODY subtyp...

Background: Acromegaly is a rare condition characterised primarily by tumourous production of excess Growth Hormone (GH) from a pituitary adenoma. The Octreotide Challenge Test (OCT) has been used in the RVI to predict short term efficacy of long-acting Somatostatin Analogue (SSA) therapy.Aims: We retrospectively reviewed the OCT results of all patients with acromegaly treated at RVI from 2005 to 2021 to evaluate its clinical utility.<p class="abstex...

Introduction: Conn’s syndrome is a well-known cause of secondary hypertension; however, its association with pregnancy is rare. We discuss an interesting case of Conn syndrome presented with severe hypertension 8 weeks post-partum.Case report: A 34-years-old lady, previously fit and well, presented with severe hypertension (blood pressure–189/115 mmHg) and hypokalaemia (K-2.5 mmol/l) at 8 weeks post-partum. Antenatal records indicated she was n...

Adrenal haemorrhage is a serious condition that can result in adrenal insufficiency, shock, acute adrenal crisis, and mortality if not managed with adequate treatment. Hereby we present two cases of non-traumatic bilateral adrenal haemorrhage highlighting their management during the acute phase.Case 1: 57 year old female presented due to chest pain, palpitations and troponin rise with a background history of antiphospholipid syndrome on anticoagulation. ...

Diagnostic work-up for Cushing Syndrome (CS) can be challenging and is based on clinical and biochemical assessment. Biochemical evidence of endogenous steroid excess is demonstrated through overnight dexamethasone suppression test (ODST), low dose dexamethasone suppression test and/or 24-hour urinary free cortisol estimation (UFC). Once endogenous steroid excess is confirmed, random serum ACTH measurement is key in determining the suspected source of steroid excess: ACTH-inde...

Section 1: Case: A 42-year-old woman developed central chest pain four hours after undergoing right mastectomy for intraductal breast carcinoma. Serial blood pressures were recorded as significantly elevated, up to 240/130mmHg. There was no history of new-onset headaches, palpitations, anxiety, hirsutism, change in weight or easy bruising. She had no other significant past medical history or family history. Section 2: Investigations : An electrocardiogra...

Case history: 29 year old lady presented to A&E with UTI. She had a history of emotionally unstable personality disorder and was an elective inpatient in a psychiatric hospital at the time of her presentation. Blood tests done on admission showed that she was hypercalcaemic. She was treated for UTI and referred to endocrinology. Biochemistry tests were in keeping with familial hypocalciuric hypercalcaemia (FHH). It transpired that her father and sister also had hypercalcae...

Introduction: Paragangliomas are neuroendocrine tumours, usually found from the base of the skull to pelvis. They are extremely rare in the sellar and parasellar region which normally lacks paraganglion cells. We report a rare case of an incidental sellar paraganglioma.Case: A 66 years old female had progressive retinopathy and maculopathy of unclear cause since 2011. Lung nodules were seen on CT performed to exclude paraneoplastic retinopathy. 18F-FDG P...

Case history: A 74 years old lady with background of hypertension and asthma had multiple admissions with funny turns, dizziness and double vision for at least 2 years. She was seen by various medical specialties including cardiology, stroke medicine and rheumatology before she was noticed to have a capillary glucose of 1.2 mmol/l. Whipple’s triad was demonstrated during evaluation. Supervised fasting confirmed biochemical evidence of endogenous hyperinsulinaemia with ina...

Case report: Central neurocytomas are well-differentiated rare central nervous system tumours. These tumours when identified in brain parenchyma or spinal cord are termed as extra ventricular neurocytomas. We report a case of 40 year old lady with mild hypertension who presented with long standing history of intermittent headaches which got worse 2 months before presentation, mainly affecting her forehead and left retro-orbital region. She also noted blurring of vision in her ...